dissolution problem with micronized drug

[prasanna]

It is a common techniqe of micrnizing the drug if it is showing lesser dissolution. But on stability the product is showing lesser dissolution, though it is showing good dissolution initially.
I think the problem may be due to the higher surface free energy due to the micronization, due to which it may agglomerate and giving lesser dissolution.

I think this question is related to formulation.

can u comment on whether it is true with the micronized drug or any other reason with the decrease in dissolution.

revert me back

[Vivek]

dear prasanna
i also agree with u tht micronized drug has more surface energy,but i am sure tht micronisation of the drug leads to better dissolution.can u tell me the size to with u have micronized the drug and also the other exciepients u have used in ur formulation

[prasanna]

Dear vivek
as per ur reply the average particle size of the drug is 70-100microgram.
The decrease may not happens to every drug which were micronized, but i need dats which type of drug is most susceptible for this type of problem. If u r having any datas please provide me.
prasanna

[sarvesh]

dear prasanna,
Have u tried intrinsic dissolution, since micronised API give better dissolution.:rolleyes:

[johnt]

During the injital testing and the later testing of the product were there perceptable differences in the way the dossage disntegrated. If the way the product disintegates is different it was most likely affected by the enviornemtal conditions in which it was stored.

[prasanna]

As per ur suggestion I have seen the Disintegration, but there is not somuch difference. But tell me whether this may happens any developmental dosage form u have seen or worked.
prasanna

[johnt]

I have seen some products break up and disntegrate very differnently based on the enviornmental conditions in which they are exposed. One of the reasons for dissolution testing is to ensure that the dissolution of the product is the same under both normal and stressed conditions.

[osamak1]

Results of caalibration usingApp.1, failed with Salicylic Acid Tablets (1tablet from 6 tablets) on ****** **** connected to **** ** Spectrophotometer

[henderson2000]

Pls, pay attention to whether the crystal form of the drug has been changed during the process of micronization.
second, whether the micronized drug is hard to be moistened and tends to aggregate.