How does the work get done?

[Apple]

This is not a technical question, but an organizational one. How is the dissolution work done at your company? Is there a specific group or does everyone perform the work? Is there a dissolution group leader? How does this person/group interface with the rest of the organization? At my company, we are struggling how to most efficiently and accurately accomplish all the dissolution testing that needs to be done. Any comments, suggestions, input that I may elicit from this forum would be most appreciated.

[atgaadesh]

there is no need of a dedicated dissolution group u can perform it by any trained person who can also do routine analysis,there in no need of specisl dissolution group or a group leader as in many companies it is a routin practise of dissolution

[johnt]

I have worked in companies were this has been done both ways. I have always felt it is best to have a sigle group that performs dissolution and drug release testing. Dissolution can be quite time intensive and it is easier to get into a rhythm if all you do is dissolution testing. It is also seems to be easier on the equipment. If an analyst always use the same instrumentthey have a tendency to take better care of the system

[kgauger]

I agree with John. Dissolution is really just like most other forms of testing. There are different factors that go into determining if a single group should perform the testing. The amount of testing to be done and the complexity of the testing are important. Different dissolution tests may be totally unrelated and any advantage to having a group would be lost in that case. There are also many similar tests where having the same two or three people running the baths on a schedule are really useful.

At my company we don't officially designate dissolution groups. We divide work by products and within the product groups we tend to have analysts who do mostly dissolution testing.

[harthur]

I've seen labs do both ways. My most recent time working in the lab, we divided work by product not test. I agree with John that the same person running the same piece of equipment all the time will tend to take better care of it. Although as someone who did nothing but dissolution testing for a 4 month period at one point, it is nice to rotate tests. Ultimately, I don't think one way is better than any other.

[ASR]

In our company we divide dissolution work from the other. But it surely depends on the amount of the work, if it is efficient to have extra persons for this work. One advantage of having a special dissolution-group is, that they have expierience on this subject and normally make fewer mistakes.

[qwerty]

In our company we divide dissolution work from the other. But it surely depends on the amount of the work, if it is efficient to have extra persons for this work. One advantage of having a special dissolution-group is, that they have expierience on this subject and normally make fewer mistakes.
I definately think a designated group doing dissolution is a good idea.

[douglasgm]

In our area we are dissolution specific in research, but QA is not. It can be helpful in having a dedicated group during method development, as interpretation of dissolution methods is not as straight forward as other techniques.